TRANSCRIPTION AND REPLICATION IN FILOVIRUS

Innovative Scientific Research Laboratory

The common feature among filovirus is that their genome is encoded in a negative-sense, non-segmented RNA strand, and as such, RNA regulation takes center stage in orchestrating the infection cycle of these viruses. We investigate how small RNAs and RNA binding protein govern the balance between transcription and replication in Filovirus to elucidate fundamental mechanisms of RNA regulation that control viral infection. To this end, we capitalize in our long-standing collaboration with the group of Prof. Mühlberger at the National Emerging Disease Laboratory (NEIDL) at Boston University.